Penipyrols C-G and methyl-penipyrol A, α-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131.

Authors :: Wang L
Shi Y
Che Q
Zhu T
Zhang G
Zhang X
Li M
Li D
Source :: Bioorganic chemistry [Bioorg Chem] 2021 Aug; Vol. 113, pp. 104975. Date of Electronic Publication: 2021 May 18.
Publication Year :: 2021
Abstract: Six new α-pyrone polyketides, penipyrols C-G (1-5) and methyl-penipyrol A (6), together with one biogenetically related known compound, penipyrol A (7), were isolated from the extract of fungus Penicillium sp. HDN-11-131. Their structures including the absolute configurations were established by extensive spectroscopic analysis, Mosher's method, and ECD calculations as well as biogenic considerations. Compounds 1-4 possess a rare skeleton featuring γ-butyrolactone linked to α-pyrone ring through double bond. Compound 1 can induce pancreatic β-cell regeneration in zebrafish at 10 μM, which demonstrated promising anti-diabetes potential.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Dose-Response Relationship, Drug
Hypoglycemic Agents chemistry
Hypoglycemic Agents isolation & purification
Molecular Structure
Polyketides chemistry
Polyketides isolation & purification
Pyrones chemistry
Pyrones isolation & purification
Regeneration drug effects
Structure-Activity Relationship
Zebrafish
Hypoglycemic Agents pharmacology
Insulin-Secreting Cells drug effects
Penicillium chemistry
Polyketides pharmacology
Pyrones pharmacology

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