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Resident Memory T Cells in Autoimmune Skin Diseases.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 May 03; Vol. 12, pp. 652191. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Tissue resident memory T cells (TRM) are a critical component of the immune system, providing the body with an immediate and highly specific response against pathogens re-infecting peripheral tissues. More recently, however, it has been demonstrated that TRM cells also form during autoimmunity. TRM mediated autoimmune diseases are particularly destructive, because unlike foreign antigens, the self-antigens are never cleared, continuously activating self-reactive TRM T cells. In this article, we will focus on how TRMs mediate disease in autoimmune skin conditions, specifically vitiligo, psoriasis, cutaneous lupus erythematosus, alopecia areata and frontal fibrosing alopecia.<br />Competing Interests: JH is the founder of Villaris Therapeutics and NIRA Biosciences. JH and JR are inventors on patent application #62489191, “Diagnosis and Treatment of Vitiligo” which covers targeting IL-15 and TRM for the treatment of vitiligo; and on patent application #15/851,651, “Anti-human CXCR3 antibodies for the Treatment of Vitiligo” which covers targeting CXCR3 for the treatment of vitiligo. JR is a reviewer for Frontiers Immunology journal.<br /> (Copyright © 2021 Ryan, Harris and Richmond.)
- Subjects :
- Autoantigens immunology
Autoimmune Diseases drug therapy
Autoimmune Diseases genetics
Autoimmune Diseases pathology
CD4-Positive T-Lymphocytes drug effects
CD8-Positive T-Lymphocytes drug effects
Humans
Immunologic Factors pharmacology
Immunologic Memory drug effects
Immunologic Memory genetics
Skin immunology
Skin pathology
Skin Diseases drug therapy
Skin Diseases genetics
Skin Diseases pathology
Autoimmune Diseases immunology
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Immunologic Factors therapeutic use
Skin Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34012438
- Full Text :
- https://doi.org/10.3389/fimmu.2021.652191