Back to Search
Start Over
Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization.
- Source :
-
Communications biology [Commun Biol] 2021 May 19; Vol. 4 (1), pp. 597. Date of Electronic Publication: 2021 May 19. - Publication Year :
- 2021
-
Abstract
- The COVID-19 pandemic continues to wreak havoc as worldwide SARS-CoV-2 infection, hospitalization, and death rates climb unabated. Effective vaccines remain the most promising approach to counter SARS-CoV-2. Yet, while promising results are emerging from COVID-19 vaccine trials, the need for multiple doses and the challenges associated with the widespread distribution and administration of vaccines remain concerns. Here, we engineered the coat protein of the MS2 bacteriophage and generated nanoparticles displaying multiple copies of the SARS-CoV-2 spike (S) protein. The use of these nanoparticles as vaccines generated high neutralizing antibody titers and protected Syrian hamsters from a challenge with SARS-CoV-2 after a single immunization with no infectious virus detected in the lungs. This nanoparticle-based vaccine platform thus provides protection after a single immunization and may be broadly applicable for protecting against SARS-CoV-2 and future pathogens with pandemic potential.
- Subjects :
- Animals
Antibodies, Neutralizing biosynthesis
Antibodies, Viral biosynthesis
COVID-19 Vaccines genetics
COVID-19 Vaccines immunology
Drug Delivery Systems
Female
Humans
Immunization methods
Levivirus genetics
Levivirus immunology
Mesocricetus
Microscopy, Electron, Transmission
Models, Animal
Nanoparticles administration & dosage
Nanoparticles ultrastructure
Nanotechnology
Protein Engineering
Spike Glycoprotein, Coronavirus administration & dosage
Spike Glycoprotein, Coronavirus immunology
Vaccines, Combined administration & dosage
Vaccines, Combined genetics
Vaccines, Combined immunology
Vaccines, Virus-Like Particle administration & dosage
Vaccines, Virus-Like Particle genetics
Vaccines, Virus-Like Particle immunology
COVID-19 immunology
COVID-19 prevention & control
COVID-19 Vaccines administration & dosage
Pandemics prevention & control
SARS-CoV-2 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2399-3642
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Communications biology
- Publication Type :
- Academic Journal
- Accession number :
- 34011948
- Full Text :
- https://doi.org/10.1038/s42003-021-02128-8