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Study on the preventive effect of intravenous esomeprazole in the management of nonvarices upper gastrointestinal bleeding.
- Source :
-
Medicine [Medicine (Baltimore)] 2021 May 21; Vol. 100 (20), pp. e25420. - Publication Year :
- 2021
-
Abstract
- Abstract: This retrospective study investigated the preventive effect of intravenous esomeprazole (IVEO) in the prevention of nonvarices upper gastrointestinal bleeding (NUGIB).This study enrolled 130 patients with NUGIB and all of them underwent successful endoscopic hemostasis, of which 65 cases received routine management and IVEO (Group A) and the other 65 cases received routine management alone (Group B). The primary outcome (recurrent bleeding rate within 72-hour, 7-day, and 30-day), and secondary outcomes ((all-cause mortality, bleeding-related mortality, blood transfused, hospital stay (day), and incidence of adverse events)) were compared between 2 groups.Patients in the group A showed lower recurrent bleeding rate within 72-hour(P < .05), 7-day (P < .05), and 30-day (P < .05), than that of patients in the group B. However, no significant differences were identified in all-cause mortality(P = .26), bleeding-related mortality (P = .57), blood transfused (P = .33), and hospital stay (P = .74) between 2 groups. In addition, both groups had similar safety profile.This study found that routine management and IVEO was superior to the routine management alone for preventing the recurrent bleeding rate after successful endoscopic hemostasis in patients with NUGIB.<br />Competing Interests: The authors have no conflicts of interests to disclose.<br /> (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Blood Transfusion statistics & numerical data
Combined Modality Therapy methods
Combined Modality Therapy statistics & numerical data
Female
Hospital Mortality
Humans
Infusions, Intravenous statistics & numerical data
Length of Stay statistics & numerical data
Male
Middle Aged
Peptic Ulcer Hemorrhage mortality
Recurrence
Retrospective Studies
Secondary Prevention statistics & numerical data
Treatment Outcome
Young Adult
Esomeprazole administration & dosage
Hemostasis, Endoscopic statistics & numerical data
Peptic Ulcer Hemorrhage therapy
Proton Pump Inhibitors administration & dosage
Secondary Prevention methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 100
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34011021
- Full Text :
- https://doi.org/10.1097/MD.0000000000025420