Cytotoxic lanostane triterpenoids from the ethanol extract of Schisandra viridis .

Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A ( 1 ), 29-hydroxyl schiglausin D ( 2 ), and 6-hydroxyl schiglausin G ( 3 ), were isolated from the ethanol extract of the stems of Schisandra viridis . Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D ( ¹ H - ¹ H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC ₅₀ values less than 10 μM.