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Interleukin (IL)-13/IL-22/IL-31 skewing within the skin-homing T-cell population in papuloerythroderma.
- Source :
-
The Journal of dermatology [J Dermatol] 2021 Sep; Vol. 48 (9), pp. 1357-1364. Date of Electronic Publication: 2021 May 18. - Publication Year :
- 2021
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Abstract
- Papuloerythroderma (PEO) is a representative form of senile erythroderma with an unclear pathogenesis. This study aimed to characterize the T-cell phenotypes responsible for the pathogenesis of PEO. Cytokine profiles and cutaneous lymphocyte antigen (CLA) expression on circulating T lymphocytes in patients with PEO were simultaneously analyzed using flow cytometry. The patients with PEO showed significantly higher circulating interleukin (IL)-4-, IL-13-, IL-22-, and IL-31-producing CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T-cell levels than healthy subjects. However, their levels significantly decreased after remission of PEO. No difference was observed in the proportions of circulating interferon (IFN)-γ- and IL-17-producing CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T cells between the patients with PEO and healthy subjects. In particular, the proportion of circulating IL-4-, IL-13-, IL-22-, and IL-31-producing CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T cells was much higher in the CLA <superscript>+</superscript> subset than in the CLA <superscript>-</superscript> subset. There was a positive correlation between IL-13-, IL-22-, and IL-31-producing CD4 <superscript>+</superscript> T cells and the disease severity score of PEO. Moreover, a positive correlation was also observed between the proportion of IL-22- or IL-31-producing cells and circulating IL-13-producing cells in both CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T cells, and approximately 50% of both IL-22- and IL-31-producing CD4 <superscript>+</superscript> and CD8 <superscript>+</superscript> T cells coproduced IL-13. IL-13/IL-22/IL-31 skewing within the skin-homing T-cell population may be involved in the pathogenesis of PEO.<br /> (© 2021 Japanese Dermatological Association.)
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 48
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 34002882
- Full Text :
- https://doi.org/10.1111/1346-8138.15937