Back to Search
Start Over
Targeted pH switched europium complexes monitoring receptor internalisation in living cells.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Jun 10; Vol. 57 (47), pp. 5814-5817. - Publication Year :
- 2021
-
Abstract
- We report the design and evaluation of pH responsive luminescent europium(iii) probes that allow conjugation to targeting vectors to monitor receptor internalisation in cells. The approach adopted here can be used to tag proteins selectively and to monitor uptake into more acidic organelles, thereby enhancing the performance of time-resolved internalisation assays that require pH monitoring in real time.
- Subjects :
- Coordination Complexes chemical synthesis
Exenatide pharmacology
Glucagon-Like Peptide-1 Receptor agonists
HEK293 Cells
Humans
Hydrogen-Ion Concentration
Luminescent Agents chemical synthesis
Luminescent Measurements
Optical Imaging
Coordination Complexes chemistry
Europium chemistry
Glucagon-Like Peptide-1 Receptor analysis
Luminescent Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34002181
- Full Text :
- https://doi.org/10.1039/d1cc01029h