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Chemical Characterization, Antioxidant and Cytotoxic Activities of the Edible Fruits of Brosimun gaudichaudii Trécul, a Native Plant of the Cerrado Biome.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2021 Jul; Vol. 18 (7), pp. e2001068. Date of Electronic Publication: 2021 Jun 14. - Publication Year :
- 2021
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Abstract
- In Brazil, there is a large diversity of species of small edible fruits that are considered sources of nutrients and functional properties. They present a high innovation domain for the pharmaceutical, cosmetic and food industries due to their health-promoting properties. Edible fruits from Brosimum gaudichaudii (Moraceae) are widely consumed and used in folk medicine and in feed by the population of the Brazilian Cerrado. Nevertheless, detailed information on the chemical fingerprint, antiradical activity and safety aspects of these fruits is still unknown. Thus, the aim of this work was to investigate the bioactive compounds of hydroethanolic extracts of fruits from Brosimum gaudichaudii using high-performance liquid chromatography combined with mass spectrometry using electrospray ionization (HPLC ESI-MS). Eighteen different compounds, including flavonoids, coumarins, arylbenzofurans, terpenoids, stilbenes, xanthones and esters, were detected. Moreover, the study indicated that the hydroethanolic extract of fruits from B. gaudichaudii presented low scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radicals (IC <subscript>50</subscript> >800 μg mL <superscript>-1</superscript> ) and was cytotoxic (IC <subscript>50</subscript> <30 μg mL <superscript>-1</superscript> ) in Chinese hamster ovary cells (CHO-K1) by an in vitro assay. This is the first report of the chemical profile, antioxidant activity and cytotoxic properties of the hydroethanolic extract of fruits from B. gaudichaudii.<br /> (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antioxidants chemistry
Antioxidants isolation & purification
Biphenyl Compounds antagonists & inhibitors
Brazil
Cell Line
Cell Survival drug effects
Cricetulus
Fruit chemistry
Humans
Molecular Structure
Picrates antagonists & inhibitors
Plant Extracts chemistry
Plant Extracts isolation & purification
Plants, Edible chemistry
Antineoplastic Agents, Phytogenic pharmacology
Antioxidants pharmacology
Moraceae chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 18
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 33998146
- Full Text :
- https://doi.org/10.1002/cbdv.202001068