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Decay of Fc-dependent antibody functions after mild to moderate COVID-19.
- Source :
-
Cell reports. Medicine [Cell Rep Med] 2021 Jun 15; Vol. 2 (6), pp. 100296. Date of Electronic Publication: 2021 May 09. - Publication Year :
- 2021
-
Abstract
- The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectious diseases. The evolution of such antibodies during convalescence from coronavirus disease 2019 (COVID-19) is largely unknown. We develop assays to measure Fc-dependent antibody functions against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-expressing cells in serial samples from subjects primarily with mild-moderate COVID-19 up to 149 days post-infection. We find that S-specific antibodies capable of engaging Fcγ receptors decay over time, with S-specific antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent phagocytosis (ADP) activity within plasma declining accordingly. Although there is significant decay in ADCC and ADP activity, they remain readily detectable in almost all subjects at the last time point studied (94%) in contrast with neutralization activity (70%). Although it remains unclear the degree to which Fc effector functions contribute to protection against SARS-CoV-2 re-infection, our results indicate that antibodies with Fc effector functions persist longer than neutralizing antibodies.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2021 The Author(s).)
- Subjects :
- Antibodies, Viral blood
Antibody-Dependent Cell Cytotoxicity immunology
COVID-19 pathology
COVID-19 virology
Cell Line, Tumor
Dimerization
Humans
Immunoglobulin Fc Fragments genetics
Immunoglobulin Fc Fragments immunology
Kinetics
Neutralization Tests
Phagocytosis
SARS-CoV-2 immunology
SARS-CoV-2 isolation & purification
SARS-CoV-2 metabolism
Severity of Illness Index
Spike Glycoprotein, Coronavirus genetics
Spike Glycoprotein, Coronavirus immunology
Spike Glycoprotein, Coronavirus metabolism
Antibodies, Viral metabolism
COVID-19 immunology
Immunoglobulin Fc Fragments metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2666-3791
- Volume :
- 2
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell reports. Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33997824
- Full Text :
- https://doi.org/10.1016/j.xcrm.2021.100296