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Protein kinase CK2: a potential therapeutic target for diverse human diseases.
- Source :
-
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 May 17; Vol. 6 (1), pp. 183. Date of Electronic Publication: 2021 May 17. - Publication Year :
- 2021
-
Abstract
- CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates (either viral and host proteins). CK2 is also considered an emerging target for neurological diseases, inflammation and autoimmune disorders, diverse ophthalmic pathologies, diabetes, and obesity. In addition, CK2 activity has been associated with cardiovascular diseases, as cardiac ischemia-reperfusion injury, atherosclerosis, and cardiac hypertrophy. The hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many years. Moreover, psychiatric disorders and syndromes due to CK2 mutations have been recently identified. On these bases, CK2 is emerging as an increasingly attractive target in various fields of human medicine, with the advantage that several very specific and effective inhibitors are already available. Here, we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.
- Subjects :
- Humans
Mutation
Phosphorylation
Signal Transduction drug effects
Signal Transduction genetics
COVID-19 enzymology
COVID-19 genetics
Cardiovascular Diseases drug therapy
Cardiovascular Diseases enzymology
Cardiovascular Diseases genetics
Casein Kinase II antagonists & inhibitors
Casein Kinase II genetics
Casein Kinase II metabolism
Cystic Fibrosis drug therapy
Cystic Fibrosis enzymology
Cystic Fibrosis genetics
Eye Diseases drug therapy
Eye Diseases enzymology
Eye Diseases genetics
Mental Disorders drug therapy
Mental Disorders enzymology
Mental Disorders genetics
Protein Kinase Inhibitors therapeutic use
SARS-CoV-2
COVID-19 Drug Treatment
Subjects
Details
- Language :
- English
- ISSN :
- 2059-3635
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Signal transduction and targeted therapy
- Publication Type :
- Academic Journal
- Accession number :
- 33994545
- Full Text :
- https://doi.org/10.1038/s41392-021-00567-7