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Exploitation of blood non-Newtonian properties for ultrasonic measurement of hematocrit.

Authors :
Pialot B
Gachelin J
Provost J
Couture O
Source :
Scientific reports [Sci Rep] 2021 May 13; Vol. 11 (1), pp. 10208. Date of Electronic Publication: 2021 May 13.
Publication Year :
2021

Abstract

New processing techniques for manipulating blood and its components at a microfluidic scale are currently implemented. As for extracorporeal circulation, the in-line evaluation and monitoring of blood properties during these microfluidic techniques is a challenging task. Here, we show that the blood hematocrit can be measured non-invasively in a sub-millimeter medical tube using the non-Newtonian behavior of blood velocity profile. This hematocrit measurement is demonstrated on human blood with a simple Doppler ultrasound system. Results show a mean measurement error of 4.6 ± 1.3%Hct for hematocrit up to 52% and for 5 s-long ultrasonic signals. The simplicity and the measurement scale of the approach make it highly valuable for measuring hematocrit in new blood separation techniques. The approach may have an impact on in-vitro blood processing in general.

Details

Language :
English
ISSN :
2045-2322
Volume :
11
Issue :
1
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
33986398
Full Text :
https://doi.org/10.1038/s41598-021-89704-4