Back to Search
Start Over
Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination.
- Source :
-
Nature communications [Nat Commun] 2021 May 11; Vol. 12 (1), pp. 2626. Date of Electronic Publication: 2021 May 11. - Publication Year :
- 2021
-
Abstract
- By conferring systemic protection and durable benefits, cancer immunotherapies are emerging as long-term solutions for cancer treatment. One such approach that is currently undergoing clinical testing is a therapeutic anti-cancer vaccine that uses two different viruses expressing the same tumor antigen to prime and boost anti-tumor immunity. By providing the additional advantage of directly killing cancer cells, oncolytic viruses (OVs) constitute ideal platforms for such treatment strategy. However, given that the targeted tumor antigen is encoded into the viral genomes, its production requires robust infection and therefore, the vaccination efficiency partially depends on the unpredictable and highly variable intrinsic sensitivity of each tumor to OV infection. In this study, we demonstrate that anti-cancer vaccination using OVs (Adenovirus (Ad), Maraba virus (MRB), Vesicular stomatitis virus (VSV) and Vaccinia virus (VV)) co-administered with antigenic peptides is as efficient as antigen-engineered OVs and does not depend on viral replication. Our strategy is particularly attractive for personalized anti-cancer vaccines targeting patient-specific mutations. We suggest that the use of OVs as adjuvant platforms for therapeutic anti-cancer vaccination warrants testing for cancer treatment.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Animals
Antigens, Neoplasm genetics
Antigens, Neoplasm immunology
Cancer Vaccines genetics
Cancer Vaccines immunology
Cell Line, Tumor
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Disease Models, Animal
Female
Humans
Mice
Neoplasms immunology
Oncolytic Viruses genetics
Poly I-C administration & dosage
Poly I-C immunology
Vaccines, Subunit administration & dosage
Vaccines, Subunit genetics
Vaccines, Subunit immunology
Vaccinia virus
Vesicular stomatitis Indiana virus
Xenograft Model Antitumor Assays
Antigens, Neoplasm administration & dosage
Cancer Vaccines administration & dosage
Neoplasms therapy
Oncolytic Virotherapy methods
Oncolytic Viruses immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33976179
- Full Text :
- https://doi.org/10.1038/s41467-021-22929-z