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Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats.
- Source :
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Journal of ethnopharmacology [J Ethnopharmacol] 2021 Aug 10; Vol. 276, pp. 114193. Date of Electronic Publication: 2021 May 08. - Publication Year :
- 2021
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Abstract
- Ethnopharmacological Relevance: Lavandula angustifolia Mill. Essential oil (Lavender EO) has a long history of medicinal use and is particularly claimed to possess anxiolytic and sedative properties. Lavender EO aromatherapy has been used to reduce distress and improve insomnia naturally. Increasing evidence appeared to show similarities between the effects of lavender EO and the anxiolytic drugs, benzodiazepines. However, its effects on sleep-wake and electrical brain patterns in comparison to that of the standard anxiolytic, diazepam, remained to be explored.<br />Aim of the Study: The aim of this work was to investigate electroencephalography (EEG) profiles and sleep-pattern elicited by lavender EO inhalation compared to that of diazepam, a standard anxiolytic drug in in vivo rat model.<br />Materials and Methods: Adult male Wistar rats were anesthetized for electrode implantation on the frontal and parietal skulls. EEG signals were recorded for 180 min following intraperitoneal injection of diazepam (10 mg/kg) or during continuous inhalation of lavender EO (200 μL) or distilled water (control). Fast Fourier transform was used for the analyses of EEG power spectra and sleep-wake parameters.<br />Results: During a 30-60 min period, diazepam and lavender EO significantly increased frontal powers of 0.78-45.31 and 7.03-18.36 Hz, respectively. Both treatments also increased parietal powers with lower magnitudes of significant change. Significant increases in some frequency ranges remained until a 60-90 min period. Sleep-wake analyses also revealed that diazepam significantly reduced time spent in wake, increased time spent in non-rapid eye movement (NREM), increased episode duration of NREM, decreased numbers of wake episode and decreased rapid eye movement (REM) sleep latency. On the other hand, lavender EO only significantly decreased wake episodes and latency to REM sleep. Lavender EO inhalation reduced numbers of wake episode but maintain normal time spent in wake, NREM and REM sleeps.<br />Conclusions: These findings might suggest beneficial and distinct anxiolytic-like effects of lavender EO for sleep enhancing purposes.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Inhalation
Animals
Anti-Anxiety Agents administration & dosage
Brain drug effects
Diazepam administration & dosage
Electroencephalography drug effects
Hypnotics and Sedatives administration & dosage
Injections, Intraperitoneal
Male
Oils, Volatile administration & dosage
Plant Oils administration & dosage
Rats, Wistar
Sleep drug effects
Wakefulness drug effects
Rats
Anti-Anxiety Agents pharmacology
Diazepam pharmacology
Hypnotics and Sedatives pharmacology
Lavandula chemistry
Oils, Volatile pharmacology
Plant Oils pharmacology
Sleep Disorders, Circadian Rhythm drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 276
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 33971301
- Full Text :
- https://doi.org/10.1016/j.jep.2021.114193