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Quantification of Myocardial Mitochondrial Membrane Potential Using PET.
- Source :
-
Current cardiology reports [Curr Cardiol Rep] 2021 May 10; Vol. 23 (6), pp. 70. Date of Electronic Publication: 2021 May 10. - Publication Year :
- 2021
-
Abstract
- Purpose of Review: To present a method enabling in vivo quantification of tissue membrane potential (ΔΨ <subscript>T</subscript> ), a proxy of mitochondrial membrane potential (ΔΨ <subscript>m</subscript> ), to review the origin and role of ΔΨ <subscript>m</subscript> , and to highlight potential applications of myocardial ΔΨ <subscript>T</subscript> imaging.<br />Recent Findings: Radiolabelled lipophilic cations have been used for decades to measure ΔΨ <subscript>m</subscript> in vitro. Using similar compounds labeled with positron emitters and appropriate compartment modeling, this technique now allows in vivo quantification of ΔΨ <subscript>T</subscript> with positron emission tomography. Studies have confirmed the feasibility of measuring myocardial ΔΨ <subscript>T</subscript> in both animals and humans. In addition, ΔΨ <subscript>T</subscript> showed very low variability among healthy subjects, suggesting that this method could allow detection of relatively small pathological changes. In vivo assessment of myocardial ΔΨ <subscript>T</subscript> provides a new tool to study the pathophysiology of cardiovascular diseases and has the potential to serve as a new biomarker to assess disease stage, prognosis, and response to therapy.
Details
- Language :
- English
- ISSN :
- 1534-3170
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Current cardiology reports
- Publication Type :
- Academic Journal
- Accession number :
- 33970353
- Full Text :
- https://doi.org/10.1007/s11886-021-01500-8