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Hot or cold: Bioengineering immune contextures into in vitro patient-derived tumor models.

Authors :
Too NSH
Ho NCW
Adine C
Iyer NG
Fong ELS
Source :
Advanced drug delivery reviews [Adv Drug Deliv Rev] 2021 Aug; Vol. 175, pp. 113791. Date of Electronic Publication: 2021 May 07.
Publication Year :
2021

Abstract

In the past decade, immune checkpoint inhibitors (ICI) have proven to be tremendously effective for a subset of cancer patients. However, it is difficult to predict the response of individual patients and efforts are now directed at understanding the mechanisms of ICI resistance. Current models of patient tumors poorly recapitulate the immune contexture, which describe immune parameters that are associated with patient survival. In this Review, we discuss parameters that influence the induction of different immune contextures found within tumors and how engineering strategies may be leveraged to recapitulate these contextures to develop the next generation of immune-competent patient-derived in vitro models.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-8294
Volume :
175
Database :
MEDLINE
Journal :
Advanced drug delivery reviews
Publication Type :
Academic Journal
Accession number :
33965462
Full Text :
https://doi.org/10.1016/j.addr.2021.05.001