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Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters.
- Source :
-
Organic letters [Org Lett] 2021 May 21; Vol. 23 (10), pp. 3814-3817. Date of Electronic Publication: 2021 May 07. - Publication Year :
- 2021
-
Abstract
- A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 23
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 33960795
- Full Text :
- https://doi.org/10.1021/acs.orglett.1c00796