Back to Search
Start Over
Effect of ECG-gating Retinal Photographs on Retinal Vessel Caliber Measurements in Subjects with and without Type 2 Diabetes.
- Source :
-
Current eye research [Curr Eye Res] 2021 Nov; Vol. 46 (11), pp. 1742-1750. Date of Electronic Publication: 2021 May 26. - Publication Year :
- 2021
-
Abstract
- Purpose/Aim of this study : Retinal vessel caliber is an independent risk marker of cardiovascular disease risk. However, variable mechanical delays in capturing retinal photographs and cardiac cycle-induced retinal vascular changes have been shown to reduce the accuracy of retinal vessel caliber measurements, but this has only ever been investigated in healthy subjects. This cross-sectional study is the first study to investigate this issue in type 2 diabetes. The aim of this study was to determine whether ECG-gating retinal photographs reduce the variability in retinal arteriolar and venular caliber measurements in controls and type 2 diabetes. Materials and Methods : Fifteen controls and 15 patients with type 2 diabetes were arbitrarily recruited from Westmead Hospital, Sydney, Australia. A mydriatic fundoscope connected to our novel ECG synchronization unit captured 10 ECG-gated (at the QRS) and 10 ungated digital retinal photographs of the left eye in a randomized fashion, blinded to study participants. Two independent reviewers used an in-house semi-automated software to grade single cross-sectional vessel diameters across photographs, between 900 and 1800 microns from the optic disc edge. The coefficient of variation compared caliber variability between retinal arterioles and venules. Results : Our ECG synchronization unit reported the smallest time delay (33.1 ± 48.4 ms) in image capture known in the literature. All 30 participants demonstrated a higher reduction in retinal arteriolar (ungated: 1.02, 95%CI 0.88-1.17% vs ECG-gated: 0.39, 95%CI 0.29-0.49%, p < .0001) than venular (ungated 0.62, 95%CI 0.53-0.73% vs ECG-gated: 0.26, 95%CI 0.19-0.35%, p < .0001) coefficient of variation by ECG-gating photographs. Intra-observer repeatability and inter-observer reproducibility analysis reported high interclass correlation coefficients ranging from 0.80 to 0.86 and 0.80 to 0.93 respectively. Conclusion : ECG-gating photographs at the QRS are recommended for retinal vessel caliber analysis in controls and patients with type 2 diabetes as they refine measurements.
- Subjects :
- Adult
Cardiovascular Diseases diagnostic imaging
Cross-Sectional Studies
Diabetes Mellitus, Type 2 diagnostic imaging
Diabetic Retinopathy diagnostic imaging
Female
Humans
Male
Middle Aged
Observer Variation
Ophthalmoscopes
Reproducibility of Results
Retinal Artery diagnostic imaging
Retinal Vein diagnostic imaging
Surveys and Questionnaires
Cardiovascular Diseases physiopathology
Diabetes Mellitus, Type 2 physiopathology
Diabetic Retinopathy physiopathology
Electrocardiography methods
Photography methods
Retinal Artery pathology
Retinal Vein pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2202
- Volume :
- 46
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Current eye research
- Publication Type :
- Academic Journal
- Accession number :
- 33960254
- Full Text :
- https://doi.org/10.1080/02713683.2021.1927112