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Predictive Markers of Bronchial Hyperreactivity in a Large Cohort of Young Adults With Cough Variant Asthma.

Authors :
Malerba M
Ragnoli B
Azzolina D
Montuschi P
Radaeli A
Source :
Frontiers in pharmacology [Front Pharmacol] 2021 Apr 19; Vol. 12, pp. 630334. Date of Electronic Publication: 2021 Apr 19 (Print Publication: 2021).
Publication Year :
2021

Abstract

Cough variant asthma (CVA), a common asthma phenotype characterized by nonproductive cough and bronchial hyperreactivity (BHR), is usually detected by bronchial provocation tests (BPTs) which are time - consuming, expensive, and unsafe. The primary study objective was to provide proof of concept for the use of fractional exhaled nitric oxide (F <subscript>E</subscript> NO), eosinophil count percentage in induced sputum (sEOS%), forced expiratory flow between 25 and 75% of forced vital capacity (FEF <subscript>25-75%</subscript> ) % predicted value, and FEF <subscript>25-75%</subscript> z-scores as surrogate markers predicting BHR in young adults with suspected CVA; the secondary objective was to compare the diagnostic performance of the various techniques. Three hundred and ten subjects (median age 24 years) were included in a cross-sectional study. Subjects were characterized as BHR positive (POS) ( n = 147) or BHR negative (NEG) (n = 163) according to methacholine BPT. Classification accuracies were expressed as areas under the receiver operator characteristic curves (AUC). Compared with BHR NEG, FEF <subscript>25-75%</subscript> % predicted value and FEF <subscript>25-75%</subscript> z-scores were lower in the BHR POS group ( p < 0.001), whereas F <subscript>E</subscript> NO ( p < 0.001) and sEOS% were higher ( p < 0.001). AUC values for detecting BHR were as follows: F <subscript>E</subscript> NO, 0.98 (SD = 0.02); sEOS%, 0.98 (SD = 0.02); FEF <subscript>25-75%</subscript> % pred, 0.93 (SD = 0.05); FEF <subscript>25-75%</subscript> z scores, 0.92 (SD = 0.05). Optimal cutoff values (OCV) for BHR prediction were as follows: F <subscript>E</subscript> NO, 32.7 ppb (sensitivity = 0.93, specificity = 0.96), sEOS%, 3.80% (sensitivity = 0.94, specificity = 0.94), FEF <subscript>25-75%</subscript> % predicted value, 80.0% (sensitivity = 0.90, specificity = 0.87), and FEF <subscript>25-75%</subscript> z-score, -0.87 (sensitivity = 0.89, specificity = 0.87). Non-invasive/semi-invasive airway inflammatory or small airway functional measures might be used as surrogate markers predicting BHR in young adults with suspected CVA.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Malerba, Ragnoli, Azzolina, Montuschi and Radaeli.)

Details

Language :
English
ISSN :
1663-9812
Volume :
12
Database :
MEDLINE
Journal :
Frontiers in pharmacology
Publication Type :
Academic Journal
Accession number :
33953671
Full Text :
https://doi.org/10.3389/fphar.2021.630334