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MRD Assessment in Multiple Myeloma: Progress and Challenges.
- Source :
-
Current hematologic malignancy reports [Curr Hematol Malig Rep] 2021 Apr; Vol. 16 (2), pp. 162-171. Date of Electronic Publication: 2021 May 05. - Publication Year :
- 2021
-
Abstract
- Purpose of Review: Over the last decade, the development of effective treatment approaches for multiple myeloma (MM) has been associated with higher response rates and longer survival. In patients who achieve complete response, several high sensitivity techniques have been studied to assess minimal residual disease (MRD) and detect residual neoplastic cells within the bone marrow (by flow cytometry or molecular biology techniques) or outside the bone marrow (by imaging or circulating disease markers in the peripheral blood). This is of utmost importance, since residual disease can drive clinical relapse. This review focuses on the progress made in the assessment of MRD in MM.<br />Recent Findings: The achievement of MRD negativity after therapy is considered prognostically important for MM patients, and data from clinical trials and meta-analyses have confirmed that it is strongly associated with better survival. Along with well-known techniques, such as next-generation sequencing (NGS), next-generation flow (NGF), and positron emission tomography/computed tomography (PET/CT), other methods such as mass spectrometry (MS) and circulating tumor cells are under study. Intensive treatment regimens at diagnosis can lead up to 70% of MRD negativity in MM patients, although the current proportion of curable patients is still unknown. Today, clinicians who treat MM deal with MRD assessment in routine clinical practice. Its appropriate use in therapeutic decision making may be the most fascinating and challenging issue to be addressed over the next few years.
- Subjects :
- Biomarkers, Tumor
Bone Marrow pathology
Combined Modality Therapy methods
Disease Management
Disease Susceptibility
Flow Cytometry methods
High-Throughput Nucleotide Sequencing methods
Humans
Magnetic Resonance Imaging
Multiple Myeloma etiology
Multiple Myeloma metabolism
Multiple Myeloma therapy
Positron Emission Tomography Computed Tomography
Prognosis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Treatment Outcome
Multiple Myeloma diagnosis
Neoplasm, Residual diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1558-822X
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current hematologic malignancy reports
- Publication Type :
- Academic Journal
- Accession number :
- 33950462
- Full Text :
- https://doi.org/10.1007/s11899-021-00633-5