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Impact of Cholestasis on the Sensitivity of Percutaneous Transluminal Forceps Biopsy in 93 Patients with Suspected Malignant Biliary Stricture.
- Source :
-
Cardiovascular and interventional radiology [Cardiovasc Intervent Radiol] 2021 Oct; Vol. 44 (10), pp. 1618-1624. Date of Electronic Publication: 2021 May 04. - Publication Year :
- 2021
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Abstract
- Purpose: The aim of this study was to determine the effect of hyperbilirubinemia in the sensitivity of percutaneous transluminal forceps biopsy (PTFB) in patients with suspected malignant biliary stricture.<br />Materials and Methods: Ninety-three patients with suspicion of malignant biliary stricture underwent percutaneous transhepatic cholangiography followed by PTFB. Sensitivity, specificity and predictive values were analysed based on the presence or absence of hyperbilirubinemia, defined as total bilirubin equal to, or higher than 5 mg/dL. Variables included demographic and clinical features, laboratory, tumour type and localization, stricture length, therapeutic approach and histopathology. Additionally, major morbidity and mortality were assessed.<br />Results: The overall sensitivity, specificity, positive predictive value and accuracy of PTFB were 61.1%, 100%, 100%, and 62.4%, respectively. Hyperbilirubinemia affected 57% of patients at the time of PTFB. There were 35 (37%) false negative results, none of them related to tumour type or localization, stricture length, or previous biliary intervention (i.e. PBBD (percutaneous biliary balloon dilatation), ERCP (endoscopic retrograde cholangiopancreatography)) (p > 0.05). However, when bilirubin was < 5 mg/dL, false negative results decreased globally (p = 0.024) and sensitivity increased significantly for intrahepatic and hilar localization, as well as for colorectal metastasis, gallbladder carcinoma, and pancreatic carcinoma. No major morbidity occurred.<br />Conclusion: The sensitivity of percutaneous transluminal biopsy for diagnosis of malignant stricture may significantly increase if samples are obtained in the absence of hyperbilirubinemia, without adding morbidity to the procedure.<br />Level of Evidence: Level 3, Case- Control studies.<br /> (© 2021. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).)
- Subjects :
- Biopsy
Cholangiopancreatography, Endoscopic Retrograde
Constriction, Pathologic
Humans
Sensitivity and Specificity
Surgical Instruments
Bile Duct Neoplasms complications
Bile Duct Neoplasms diagnostic imaging
Bile Duct Neoplasms therapy
Cholestasis diagnostic imaging
Cholestasis etiology
Cholestasis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1432-086X
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cardiovascular and interventional radiology
- Publication Type :
- Academic Journal
- Accession number :
- 33948696
- Full Text :
- https://doi.org/10.1007/s00270-021-02845-x