Preclinical Assessment Addressing Intravenous Administration of a [ 68 Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution.

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [ ⁶⁸ Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [ ⁶⁸ Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.