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Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30. - Publication Year :
- 2021
-
Abstract
- Understanding the host anti-fungal immunity induced by beta-glucan has been one of the most challenging conundrums in the field of biomedical research. During the last couple of decades, insights on the role of beta-glucan in fungal disease progression, susceptibility, and resistance have been greatly augmented through the utility of various beta-glucan cognate receptor-deficient mouse models. Analysis of dectin-1 knockout mice has clarified the downstream signaling pathways and adaptive effector responses triggered by beta-glucan in anti-fungal immunity. On the other hand, assessment of CR3-deficient mice has elucidated the compelling action of beta-glucans in neutrophil-mediated fungal clearance, and the investigation of EphA2-deficient mice has highlighted its novel involvement in host sensing and defense to oral mucosal fungal infection. Based on these accounts, this review focuses on the recent discoveries made by these gene-targeted mice in beta-glucan research with particular emphasis on the multifaceted aspects of fungal immunity.
- Subjects :
- Adaptive Immunity
Animals
Disease Models, Animal
Gene Deletion
Humans
Immunity
Lectins, C-Type genetics
Lectins, C-Type immunology
Macrophage-1 Antigen genetics
Macrophage-1 Antigen immunology
Mice
Mice, Knockout
Mycoses genetics
Mycoses microbiology
Receptor, EphA2 genetics
Receptor, EphA2 immunology
Fungi immunology
Mycoses immunology
beta-Glucans immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33946381
- Full Text :
- https://doi.org/10.3390/ijms22094778