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Highly Diastereoselective Hydrosilane-Assisted Rhodium-Catalyzed Spiro-Type Cycloisomerization of Succinimide and Pyrazolone-Based Functional 1,6-Dienes.
- Source :
-
Chemistry, an Asian journal [Chem Asian J] 2021 Jul 05; Vol. 16 (13), pp. 1730-1734. Date of Electronic Publication: 2021 May 18. - Publication Year :
- 2021
-
Abstract
- Organosilicon compounds are important reagents and synthetic intermediates that play a key role in the construction of new materials and complex products. Here we show a highly diastereoselective rhodium-catalyzed cycloisomerization of 1,6-dienes, in which the use of (EtO) <subscript>3</subscript> SiH accelerates the intramolecular cyclization reaction to afford a novel spiro-fused succinimide and pyrazolone derivatives in moderate to excellent yields as a single diastereoisomer. The proposed mechanism involves an active Rh-H species from the hydrosilane that is the H-donor in this spiro-type cycloisomerization reaction.<br /> (© 2021 Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1861-471X
- Volume :
- 16
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Chemistry, an Asian journal
- Publication Type :
- Academic Journal
- Accession number :
- 33945231
- Full Text :
- https://doi.org/10.1002/asia.202100372