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An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study.
- Source :
-
Radiation oncology (London, England) [Radiat Oncol] 2021 May 03; Vol. 16 (1), pp. 83. Date of Electronic Publication: 2021 May 03. - Publication Year :
- 2021
-
Abstract
- Background: This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients.<br />Methods: Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumours. Nanostring nCounter analysis of transcriptional changes was carried out in samples prior and 24 h post-delivery of the 1st radiotherapy fraction, just prior to the 5th or 6th fraction, and just before the last fraction.<br />Results: Statistical analysis with BRB-ArrayTools, GLM MANOVA and nSolver, revealed a radiation responsive panel of genes which varied by patient group (type of cancer) and with time since exposure (as an analogue for dose received), which may be useful as a biomarker of radiation response.<br />Conclusion: Further validation in a wider group of patients is ongoing, together with work towards a full understanding of patient specific responses in support of personalised approaches to radiation medicine.
- Subjects :
- Biomarkers, Tumor genetics
Breast Neoplasms blood
Breast Neoplasms genetics
Breast Neoplasms immunology
Breast Neoplasms radiotherapy
Female
Gastrointestinal Neoplasms blood
Gastrointestinal Neoplasms genetics
Gastrointestinal Neoplasms immunology
Gastrointestinal Neoplasms radiotherapy
Humans
Lung Neoplasms blood
Lung Neoplasms genetics
Lung Neoplasms immunology
Lung Neoplasms radiotherapy
Neoplasms genetics
Neoplasms immunology
Neoplasms radiotherapy
Pilot Projects
Prognosis
Urogenital Neoplasms blood
Urogenital Neoplasms genetics
Urogenital Neoplasms immunology
Urogenital Neoplasms radiotherapy
Biomarkers, Tumor blood
Gene Expression Regulation, Neoplastic radiation effects
Inflammation genetics
Neoplasms blood
Radiation, Ionizing
Transcriptome radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1748-717X
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Radiation oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33941218
- Full Text :
- https://doi.org/10.1186/s13014-021-01807-4