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Prospective Clinical Trial Evaluating the Long-Term Safety and Efficacy of Calcium Hydroxylapatite for Chest Rejuvenation.
- Source :
-
Journal of drugs in dermatology : JDD [J Drugs Dermatol] 2021 May 01; Vol. 20 (5), pp. 534-537. - Publication Year :
- 2021
-
Abstract
- Background: Calcium hydroxylapatite (CaHA) is indicated for correcting moderate-to-severe facial wrinkles and folds. Hyperdilute CaHA is increasingly being used for stimulating neocollagenesis to improve skin quality and firmness.<br />Objective: This study assessed long-term effects of hyperdilute CaHA for improving chest wrinkle appearance.<br />Methods and Materials: Adult female subjects (N=20) were treated with a 1:2 dilution of CaHA and evaluated at week 6, week 12, day 180, and day 360 using validated Merz D&eacute;colletage Scales. A Subject Satisfaction Questionnaire was used to assess overall satisfaction on a scale from 0 (Completely Dissatisfied) to 6 (Completely Satisfied).<br />Results: Subjects achieved significant improvements in baseline Merz D&eacute;colletage Scale&ndash;Dynamic scores at week 6, after a single treatment (P=0.02), at week 12 (two treatments) (P=0.01), day 180 (P=0.01), and day 360 (P&lt;0.01). Subjects also demonstrated significant improvement in baseline Merz D&eacute;colletage Scale&ndash;At Rest scores at week 6 (P&lt;0.01), remaining significant at week 12 (P&lt;0.01), day 180 (P&lt;0.01), and day 360 (P&lt;0.01). Subject Satisfaction scores increased from 3.25 at day 180 to 3.59 at day 360 using a 7-point scale.<br />Conclusion: Hyperdilute CaHA significantly improves the dynamic and resting appearance of wrinkles of the d&eacute;collet&eacute;. These durable improvements persist for at least 1 year. J Drugs Dermatol. 20(5): doi:10.36849/JDD.5680.
- Subjects :
- Adult
Aged
Dermal Fillers adverse effects
Durapatite adverse effects
Female
Follow-Up Studies
Humans
Injections, Intradermal
Middle Aged
Patient Satisfaction
Prospective Studies
Skin drug effects
Thorax
Treatment Outcome
Cosmetic Techniques adverse effects
Dermal Fillers administration & dosage
Durapatite administration & dosage
Rejuvenation
Skin Aging drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1545-9616
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of drugs in dermatology : JDD
- Publication Type :
- Academic Journal
- Accession number :
- 33938688
- Full Text :
- https://doi.org/10.36849/JDD.5680