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Doppler-Guided Acoustically Active Injection Catheter: Transendocardial Delivery Assessed by an Efficacy Testing Animal Model.
- Source :
-
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine [J Ultrasound Med] 2022 Mar; Vol. 41 (3), pp. 749-762. Date of Electronic Publication: 2021 May 03. - Publication Year :
- 2022
-
Abstract
- Percutaneous transendocardial injections of therapeutic agents into the myocardium may not always be effective. We used an animal model for assessing the efficacy of the injections using linoleic acid as a testing agent. Efficacious delivery into the myocardium of a beating heart was indicated by rapidly developed local myocardial necrosis and wall motion abnormalities using echocardiography. We employed this experimental model to test our innovative technology, an acoustically active injection catheter. The Doppler ultrasound-guided acoustically active injection catheter effectively delivers the substance to the myocardium but needs further technical improvements to minimize an unwanted systemic distribution of the agent.<br /> (© 2021 American Institute of Ultrasound in Medicine.)
Details
- Language :
- English
- ISSN :
- 1550-9613
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33938031
- Full Text :
- https://doi.org/10.1002/jum.15739