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Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: A hospital-based, case-control study (SIGES).
- Source :
-
Cancer medicine [Cancer Med] 2021 Jun; Vol. 10 (11), pp. 3741-3755. Date of Electronic Publication: 2021 May 02. - Publication Year :
- 2021
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Abstract
- Objectives: This case-control study was aimed to investigate associations between HBV infection and extrahepatic digestive system cancers.<br />Methods: The patients of gastric, small intestinal, colonic, rectal, anal, biliary tract, and pancreatic cancers were retrospectively collected between 2016.5 and 2017.12. Simultaneously, the healthy controls were collected from the health check-up registry, and cancer-free status was confirmed based on medical records. Propensity score matching was performed to reduce bias. Multinomial logit model and conditional logistic regression model were used to assess the risk of individual cancer according to HBV serological markers and classifications.<br />Results: Totally, 4748 patients involving seven cancers, and 57,499 controls were included. After matching, HBsAg was associated with increased risk of gastric cancer (aOR = 1.39, 95% CI: 1.05-1.85), and anti-HBs served as a protective factor for gastric (aOR = 0.72, 95% CI: 0.61-0.85), colonic (aOR = 0.73, 95% CI: 0.60-0.89), rectal (aOR = 0.73, 95% CI: 0.63-0.85), and pancreatic (aOR = 0.58, 95% CI: 0.42-0.82) cancers. Compared to subgroups with non-infection and vaccination status, inactive HBsAg carriers and active HBV infection subgroup were correlated with gastric carcinogenesis (aOR = 1.41, 95% CI: 1.03-1.93). However, no clear association was found between HBV infection and other cancers.<br />Conclusions: HBV infection was potentially associated with an increased risk of gastric cancer. The development mechanism of HBV-associated gastric cancer needs to investigate further.<br /> (© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Subjects :
- Anus Neoplasms blood
Anus Neoplasms etiology
Biliary Tract Neoplasms blood
Biliary Tract Neoplasms etiology
China
Colonic Neoplasms blood
Colonic Neoplasms etiology
Digestive System Neoplasms blood
Epidemiologic Factors
Female
Hepatitis B blood
Hepatitis B Surface Antigens blood
Hepatitis B virus immunology
Humans
Male
Middle Aged
Pancreatic Neoplasms blood
Pancreatic Neoplasms etiology
Rectal Neoplasms blood
Rectal Neoplasms etiology
Risk Factors
Stomach Neoplasms blood
Stomach Neoplasms etiology
Digestive System Neoplasms etiology
Hepatitis B complications
Subjects
Details
- Language :
- English
- ISSN :
- 2045-7634
- Volume :
- 10
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33934530
- Full Text :
- https://doi.org/10.1002/cam4.3901