Back to Search Start Over

Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial.

Authors :
Rahimi Sakak F
Moslehi N
Abdi H
Mirmiran P
Source :
BMC complementary medicine and therapies [BMC Complement Med Ther] 2021 May 01; Vol. 21 (1), pp. 134. Date of Electronic Publication: 2021 May 01.
Publication Year :
2021

Abstract

Background: This study was aimed to examine the effects of vitamin K2 supplementation on atherogenic status, assessed by insulin resistance (IR)-related indexes, in patients with type 2 diabetes mellitus (T2DM).<br />Methods: In this double-blind, controlled trial, 68 patients with T2DM on the oral glucose-lowering medications were randomly allocated into two groups receiving daily intakes of 360 μg MK-7 or placebo for 12 weeks. Eight different IR-related indexes were calculated at the baseline and end of the trial.<br />Results: At the end of the study, atherogenic coefficient (mean ± SD: - 0.21 ± 0.45 vs. 0.02 ± 0.43; p = 0.043), triglyceride-glucose index (8.88 ± 0.55 vs. 9.23 ± 0.69; p = 0.029), and atherogenic index of plasma (0.37 ± 0.27 vs. 0.51 ± 0.24; p = 0.031) were significantly lower in the vitamin K2 group, compared to the placebo. However, after accounting for their baseline values, the differences were no more significant. No significant differences were observed in Castelli's Ӏ and ӀӀ risk indexes, the ratio of triglycerides to high-density lipoprotein cholesterol, lipoprotein combine index, and the metabolic score for insulin resistance index between the two groups at the end of the study.<br />Conclusions: Daily intakes of 360 μg vitamin K2 in the form of MK-7 for 12 weeks could not improve the IR-related indexes of Cardiovascular Diseases risk.<br />Trial Registration: The trial was registered on Iranian Registry of Clinical Trials registry (Trial ID. IRCT20190824044592N1) on 22 December 2019. The record can be found at https://en.irct.ir/trial/41728 .

Details

Language :
English
ISSN :
2662-7671
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
BMC complementary medicine and therapies
Publication Type :
Academic Journal
Accession number :
33933059
Full Text :
https://doi.org/10.1186/s12906-021-03304-3