Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives.

Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. Over the past few years, many innovative studies have changed the way we now induce and maintain remission in AAV; achieving remission while limiting treatment toxicity is the key. This article provides an in-depth, up-to-date summary of recent trials and suggests treatment algorithms for induction and maintenance of remission based on the latest guidelines. Future possible therapies in AAV will also be discussed.
Competing Interests: Dr. Pagnoux reports grants and personal fees from Roche, personal fees from ChemoCentryx, grants and personal fees from GSK, personal fees from Sanofi, personal fees from InflaRx GmbH, and personal fees from AstraZeneca, outside the submitted work; Dr. Makhzoum reports personal fees from Hoffmann-La Roche, outside the submitted work. The other authors have no conflicts of interest.
(Copyright © 2021 Karla N. Samman et al.)