Back to Search Start Over

Ipilimumab and Stereotactic Radiosurgery with CyberKnife ® System in Melanoma Brain Metastases: A Retrospective Monoinstitutional Experience.

Authors :
Borzillo V
Di Franco R
Giannarelli D
Cammarota F
Scipilliti E
D'Ippolito E
Petito A
Serra M
Falivene S
Grimaldi AM
Simeone E
Festino L
Vanella V
Trojaniello C
Vitale MG
Madonna G
Ascierto PA
Muto P
Source :
Cancers [Cancers (Basel)] 2021 Apr 13; Vol. 13 (8). Date of Electronic Publication: 2021 Apr 13.
Publication Year :
2021

Abstract

The median overall survival (OS) and local control (LC) of patients with melanoma brain metastases (MBMs) are poor even with immune checkpoint inhibitors and/or radiotherapy (RT). The aims of the study were to evaluate the association and timing of stereotactic radiotherapy (SRT)/radiosurgery (SRS) performed with the CyberKnife <superscript>®</superscript> System and ipilimumab (IPI). A total of 63 MBMs patients were analyzed: 53 received RT+IPI and 10 RT alone. Therefore, the patients were divided into four groups: RT PRE-PI (>4 weeks before IPI) (18), RT CONC-IPI (4 weeks before/between first and last cycle/within 3 months of last cycle of IPI) (20), RT POST-IPI (>3 months after IPI) (15), and NO-IPI (10). A total of 127 lesions were treated: 75 with SRS (one fraction) and 24 with SRT (three to five fractions). The median follow-up was 10.6 months. The median OS was 10.6 months for all patients, 10.7 months for RT+IPI, and 3.3 months for NO-IPI ( p = 0.96). One-year LC was 50% for all patients, 56% for RT+IPI, and 18% for NO-IPI ( p = 0.08). The 1-year intracranial control was 45% for all patients, 44% for RT+IPI, and 51% for NO-IPI ( p = 0.73). IPI with SRS/SRT in MBMs treatment could improve LC. However, the impact and timing of the two modalities on patients' outcomes are still unclear.

Details

Language :
English
ISSN :
2072-6694
Volume :
13
Issue :
8
Database :
MEDLINE
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
33924595
Full Text :
https://doi.org/10.3390/cancers13081857