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Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

Authors :
Vrablik M
Dlouha D
Todorovova V
Stefler D
Hubacek JA
Source :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 17; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 17.
Publication Year :
2021

Abstract

Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. Although the use of genetic risk scores further improves CVD prediction, the significance is not unambiguous, and some subjects at risk remain undetected. Further research directions should focus on the "second level" of genetic information, namely, regulatory molecules (miRNAs) and epigenetic changes, predominantly DNA methylation and gene-environment interactions.

Details

Language :
English
ISSN :
1422-0067
Volume :
22
Issue :
8
Database :
MEDLINE
Journal :
International journal of molecular sciences
Publication Type :
Academic Journal
Accession number :
33920733
Full Text :
https://doi.org/10.3390/ijms22084182