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Succinate Injection Rescues Vasculature and Improves Functional Recovery Following Acute Peripheral Ischemia in Rodents: A Multimodal Imaging Study.
- Source :
-
Cells [Cells] 2021 Apr 02; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 02. - Publication Year :
- 2021
-
Abstract
- Succinate influences angiogenesis and neovascularization via a hormonelike effect on G-protein-coupled receptor 91 (GPR91). This effect has been demonstrated in the pathophysiology of diabetic retinopathy and rheumatoid arthritis. To evaluate whether succinate can play a role in acute peripheral ischemia, a preclinical study was conducted with ischemic mice treated with succinate or PBS and evaluated by imaging. Acute ischemia was followed by an increased in GPR91 expression in the ischemic muscle. As assessed with LASER-Doppler, succinate treatment resulted in an earlier and more intense reperfusion of the ischemic hindlimb compared to the control group (* p = 0.0189). A microPET study using a radiolabeled integrin ligand ([ <superscript>68</superscript> Ga]Ga-RGD <subscript>2</subscript> ) showed an earlier angiogenic activation in the succinate arm compared to control mice (* p = 0.020) with a prolonged effect. Additionally, clinical recovery following ischemia was better in the succinate group. In conclusion, succinate injection promotes earlier angiogenesis after ischemia, resulting in a more effective revascularization and subsequently a better functional recovery.
- Subjects :
- Acute Disease
Animals
Endothelial Cells metabolism
Female
Gallium Radioisotopes
Hindlimb blood supply
Hindlimb diagnostic imaging
Hindlimb physiopathology
Injections
Mice
Muscles drug effects
Muscles metabolism
Peptides, Cyclic chemistry
Perfusion
Positron Emission Tomography Computed Tomography
Receptors, G-Protein-Coupled metabolism
Succinic Acid pharmacology
Ischemia diagnostic imaging
Ischemia physiopathology
Multimodal Imaging
Neovascularization, Physiologic drug effects
Recovery of Function drug effects
Succinic Acid administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 33918298
- Full Text :
- https://doi.org/10.3390/cells10040795