Characterization of T lymphocytes in severe COVID-19 patients.

Authors :: Fenoglio D
Dentone C
Parodi A
Di Biagio A
Bozzano F
Vena A
Fabbi M
Ferrera F
Altosole T
Bruzzone B
Giacomini M
Pelosi P
De Maria A
Bassetti M
De Palma R
Filaci G
Source :: Journal of medical virology [J Med Virol] 2021 Sep; Vol. 93 (9), pp. 5608-5613. Date of Electronic Publication: 2021 May 03.
Publication Year :: 2021
Abstract: In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.<br /> (© 2021 Wiley Periodicals LLC.)