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Prognostic Value of Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease.
- Source :
-
Kidney international reports [Kidney Int Rep] 2021 Jan 16; Vol. 6 (4), pp. 953-961. Date of Electronic Publication: 2021 Jan 16 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth and a loss of functioning renal mass, but a decline in glomerular filtration rate (GFR) and onset of end-stage renal disease (ESRD) occur late in the disease course. There is therefore a great need for early prognostic biomarkers in this disorder.<br />Methods: We measured baseline serum fibroblast growth factor 23 (FGF23) levels in 192 patients with ADPKD from the Consortium for Radiologic Imaging Studies of PKD (CRISP) cohort that were followed for a median of 13 years and tested the association between FGF23 levels and change over time in height-adjusted total kidney volume (htTKV), GFR, and time to the composite endpoints of ESRD, death, and doubling of serum creatinine.<br />Results: Patients in the highest quartile for baseline FGF23 level had a higher rate of increase in htTKV (0.95% per year, P  = 0.0016), and faster rate of decline in GFR (difference of -1.03 ml/min/1.73 m <superscript>2</superscript> per year, P  = 0.005) compared with the lowest quartile, after adjusting for other covariates, including htTKV and genotype. The highest quartile of FGF23 was also associated with a substantial increase in risk for the composite endpoint of ESRD, death, or doubling of serum creatinine (hazard ratio [HR] of 2.45 in the fully adjusted model, P  = 0.03).<br />Conclusion: FGF23 is a prognostic biomarker for disease progression and clinically important outcomes in ADPKD, and has additive value to established imaging and genetic biomarkers.<br /> (© 2021 International Society of Nephrology. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 2468-0249
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Kidney international reports
- Publication Type :
- Academic Journal
- Accession number :
- 33912745
- Full Text :
- https://doi.org/10.1016/j.ekir.2021.01.004