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Ardisiatetrons A and B: tetronic acid derivatives and triterpenes from the leaves of Ardisia quinquegona and their biological activity.

Authors :
Kawakami S
Ishinaka M
Asaumi S
Sugimoto S
Inagaki M
Nishimura M
Matsunami K
Otsuka H
Shinzato T
Hyodo T
Yamaguchi K
Source :
Journal of natural medicines [J Nat Med] 2021 Jun; Vol. 75 (3), pp. 643-654. Date of Electronic Publication: 2021 Apr 27.
Publication Year :
2021

Abstract

From the leaves of Ardisia quinquegona, two alkylated tetronic acid derivatives, named ardisiatetrons A and B (1, 2), and four triterpenoids (3-6) were isolated together with one known compound (7) by a combination of various kinds of chromatography. The structure of new methyl migrated triterpene (3) was confirmed by X-ray crystallographic analysis. Compounds 2, 3, and 7 showed moderate anti-Leishmania activity and cytotoxicity towards A549 cells.

Details

Language :
English
ISSN :
1861-0293
Volume :
75
Issue :
3
Database :
MEDLINE
Journal :
Journal of natural medicines
Publication Type :
Academic Journal
Accession number :
33905079
Full Text :
https://doi.org/10.1007/s11418-021-01513-1