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Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory.
- Source :
-
Behavioural brain research [Behav Brain Res] 2021 Jul 09; Vol. 409, pp. 113320. Date of Electronic Publication: 2021 Apr 24. - Publication Year :
- 2021
-
Abstract
- Taste recognition memory is evident in rodents because the initial neophobia to novel tastes attenuates across exposures as the taste becomes familiar and safe. This attenuation of taste neophobia (AN) is context-dependent and an auditory background change could induce the recovery of the neophobic response. The AN auditory context-dependency requires the hippocampal integrity but the neurochemical mechanisms underlying the interaction with the taste memory circuit remain unexplored. We have applied pharmacological intervention by 6-hidroxydopamine (6-OHDA) hippocampal lesion for assessing the role of catecholamines in the hippocampal system to Wistar rats that drank a novel 3% vinegar solution for several consecutive days. Additionally, we manipulated the auditory background as a context that could either change or remain constant across all the drinking sessions. We found that a disruption of the context-dependent AN was induced by intracerebral administration of 6-OHDA targeted to the ventral CA1 hippocampus (vCA1). We conclude that the ability of the auditory context to modulate taste recognition memory involves the catecholaminergic activity in the ventral hippocampal circuit for the proper acquisition of safe taste memory.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
CA1 Region, Hippocampal drug effects
CA1 Region, Hippocampal metabolism
Male
Rats, Wistar
Rats
Adrenergic Agents pharmacology
Auditory Cortex physiology
Auditory Perception physiology
Behavior, Animal physiology
CA1 Region, Hippocampal physiopathology
Catecholamines metabolism
Oxidopamine pharmacology
Recognition, Psychology physiology
Taste Perception physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 409
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 33901433
- Full Text :
- https://doi.org/10.1016/j.bbr.2021.113320