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Assessment of low volume sampling technologies: utility in nonclinical and clinical studies.
- Source :
-
Bioanalysis [Bioanalysis] 2021 May; Vol. 13 (9), pp. 679-691. Date of Electronic Publication: 2021 Apr 26. - Publication Year :
- 2021
-
Abstract
- Background: Low volume sampling technologies have come a long way; however, their uptake has been slow due to logistical and perceived implementation challenges. Additional studies are needed to overcome these barriers. Materials & methods/results: Here we present two studies where different sampling technologies were evaluated to determine the feasibility of their implementation. First, we evaluated pharmacokinetic profiles for anti-gD in rats using three tail bleed sampling methods, glass capillary tubes, Shimadzu MSW2 <superscript>®</superscript>  and the Neoteryx Mitra <superscript>®</superscript> microsampler. Second, we evaluated two low volume-sampling methods to measure drug levels from patients treated with anti-A therapeutic. This evaluation used whole blood finger pricks for Neoteryx Mitra and plasma from capillary blood using TASSO OnDemand technology to compare results to established venipuncture collection method. Conclusion: These studies evaluate the feasibility and considerations for implementation of different low volume sampling technologies.
Details
- Language :
- English
- ISSN :
- 1757-6199
- Volume :
- 13
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioanalysis
- Publication Type :
- Academic Journal
- Accession number :
- 33900106
- Full Text :
- https://doi.org/10.4155/bio-2021-0027