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Association of an IFN-γ variant with susceptibility to chronic hepatitis B by the enhancement of HBV DNA replication.
- Source :
-
Cytokine [Cytokine] 2021 Jul; Vol. 143, pp. 155525. Date of Electronic Publication: 2021 Apr 23. - Publication Year :
- 2021
-
Abstract
- Interferon gamma (IFN-γ) is a crucial cytokine in host immune response to hepatitis B virus (HBV) infection. This study aimed to determine whether a functional polymorphism +874T/A in IFN-γ gene linked to high and low producer phenotypes [IFN-γ (+874T <superscript>high</superscript>  → A <superscript>low</superscript> )] may alter the outcomes of chronic HBV infection in Tunisian population. The +874T/A was analysed by ARMS-PCR method in the group of 200 patients chronically infected with HBV and 200 healthy controls. We observed that minor +874A allele, minor +874AA and +874TA genotypes were significantly more frequent in the chronic hepatitis B group in comparison to the control group [49 vs. 31%, P < 10 <superscript>-4</superscript> ; 24 vs. 13%, P < 10 <superscript>-4</superscript> ; 52 vs. 38%, P < 10 <superscript>-4</superscript> ; respectively]. Besides, they were associated with susceptibility to hepatitis B infection [OR = 2.15, 3.87 and 2.84, respectively]. The minor +874A allele and +874AA genotype were statistically more representative in the sub-group of patients with high viral DNA load when compared with the sub-group of patients with low HBV DNA load [(57% vs. 43%, P = 0.003, OR = 1.79); (33% vs. 14%, P = 0.003, OR = 3.59), respectively]. Collectively, our study suggests an association between the IFN-γ +874T/A SNP and persistence of HBV by the enhancement of HBV DNA replication.<br /> (Copyright © 2021. Published by Elsevier Ltd.)
- Subjects :
- Adult
Alleles
Case-Control Studies
DNA, Viral genetics
Female
Gene Frequency genetics
Hepatitis B, Chronic virology
Humans
Male
Viral Load genetics
DNA Replication
Genetic Association Studies
Genetic Predisposition to Disease
Hepatitis B virus physiology
Hepatitis B, Chronic genetics
Interferon-gamma genetics
Polymorphism, Single Nucleotide genetics
Virus Replication physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0023
- Volume :
- 143
- Database :
- MEDLINE
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 33896709
- Full Text :
- https://doi.org/10.1016/j.cyto.2021.155525