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Rapid detection of free and bound toxins using molecularly imprinted silica/graphene oxide hybrids.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Apr 22; Vol. 57 (33), pp. 4043-4046. - Publication Year :
- 2021
-
Abstract
- Rapid, selective detection of biological analytes is necessary for early diagnosis, but is often complicated by the analytes being bound to proteins and the lack of fast and reliable systems available for their direct assessment. Here, a cheap, easily-assembled molecularly imprinted silica/graphene oxide hybrid is developed, which can selectively detect toxins linked to early-stage chronic kidney disease, down to femtomolar concentrations within 5 minutes. The hybrid material is capable of simultaneously and separately measuring free and bound analytes using with an ultra-low limit of detection in the femtomolar range, and uses processes intrinsically adaptable to any charged molecular analyte.
- Subjects :
- Biosensing Techniques
Chitosan chemistry
Electrochemical Techniques
Electrodes
Humans
Limit of Detection
Molecular Imprinting
Surface Properties
Caffeine analysis
Creatinine analysis
Graphite chemistry
Indoles analysis
Nanoparticles chemistry
Renal Insufficiency, Chronic diagnosis
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33885678
- Full Text :
- https://doi.org/10.1039/d1cc00572c