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Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell acute lymphoblastic leukemia.
- Source :
-
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2021 Jul; Vol. 33 (4), pp. 792-796. Date of Electronic Publication: 2021 Apr 22. - Publication Year :
- 2021
-
Abstract
- An 8-y-old spayed female Beagle dog was presented with peripheral lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in peripheral blood and bone marrow samples. However, a monomorphic population of neoplastic cells different from those found in the lymph node was found in the bone marrow. T-cell acute lymphoblastic leukemia was suspected based on flow cytometric immunophenotyping. PCR for antigen receptor rearrangement (PARR) revealed clonal rearrangement of both B-cell and T-cell receptors, and the presence of both neoplastic clones in the lymph node, peripheral blood, and bone marrow. The dog was treated with multi-agent chemotherapy but died 46 d following diagnosis. Tumor staging and patient classification are needed to accurately establish a prognosis and select the most appropriate therapeutic protocol.
- Subjects :
- Animals
Antineoplastic Agents administration & dosage
Dog Diseases pathology
Dogs
Fatal Outcome
Female
Flow Cytometry veterinary
Immunophenotyping veterinary
Leukemia, T-Cell diagnosis
Leukemia, T-Cell pathology
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology
Prognosis
Dog Diseases diagnosis
Leukemia, T-Cell veterinary
Lymphoma, Large B-Cell, Diffuse veterinary
Neoplasm Staging veterinary
Precursor Cell Lymphoblastic Leukemia-Lymphoma veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1943-4936
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Publication Type :
- Academic Journal
- Accession number :
- 33884946
- Full Text :
- https://doi.org/10.1177/10406387211011024