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A 16-year study of longitudinal volumetric brain development in males with autism.
- Source :
-
NeuroImage [Neuroimage] 2021 Aug 01; Vol. 236, pp. 118067. Date of Electronic Publication: 2021 Apr 18. - Publication Year :
- 2021
-
Abstract
- Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unknown brain etiology. Our knowledge to date about structural brain development across the lifespan in ASD comes mainly from cross-sectional studies, thereby limiting our understanding of true age effects within individuals with the disorder that can only be gained through longitudinal research. The present study describes FreeSurfer-derived volumetric findings from a longitudinal dataset consisting of 607 T1-weighted magnetic resonance imaging (MRI) scans collected from 105 male individuals with ASD (349 MRIs) and 125 typically developing male controls (258 MRIs). Participants were six to forty-five years of age at their first scan, and were scanned up to 5 times over a period of 16 years (average inter-scan interval of 3.7 years). Atypical age-related volumetric trajectories in ASD included enlarged gray matter volume in early childhood that approached levels of the control group by late childhood, an age-related increase in ventricle volume resulting in enlarged ventricles by early adulthood and reduced corpus callosum age-related volumetric increase resulting in smaller corpus callosum volume in adulthood. Larger corpus callosum volume was related to a lower (better) ADOS score at the most recent study visit for the participants with ASD. These longitudinal findings expand our knowledge of volumetric brain-based abnormalities in males with ASD, and highlight the need to continue to examine brain structure across the lifespan and well into adulthood.<br /> (Copyright © 2021. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Child
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Young Adult
Autism Spectrum Disorder diagnostic imaging
Autism Spectrum Disorder pathology
Autism Spectrum Disorder physiopathology
Cerebral Ventricles diagnostic imaging
Cerebral Ventricles growth & development
Cerebral Ventricles pathology
Corpus Callosum diagnostic imaging
Corpus Callosum growth & development
Corpus Callosum pathology
Gray Matter diagnostic imaging
Gray Matter growth & development
Gray Matter pathology
Human Development physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9572
- Volume :
- 236
- Database :
- MEDLINE
- Journal :
- NeuroImage
- Publication Type :
- Academic Journal
- Accession number :
- 33878377
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2021.118067