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Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality-of-Life Studies.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2249, pp. 247-259. - Publication Year :
- 2021
-
Abstract
- Quality-of-life (QoL) outcomes are important elements of randomized controlled trials. The instruments for measurement of QoL vary but usually multiple comparisons are possible, a concern that can be offset by prespecifying the outcomes of interest. Missing data may threaten the validity of QoL assessments in trials. Therefore, familiarity with the strategies used to account for missing data is necessary. Measures that incorporate both survival and QoL are helpful for treatment decisions. The definition of minimal clinically important differences in QoL scores is important and often derived using inadequate methods.
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 2249
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 33871848
- Full Text :
- https://doi.org/10.1007/978-1-0716-1138-8_14