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Response evaluation of bone metastasis in prostate cancer: Preliminary comparison of computerized bone scan index versus standardized clinical criteria.

Response evaluation of bone metastasis in prostate cancer: Preliminary comparison of computerized bone scan index versus standardized clinical criteria.

Authors :
Petersen LJ
Gade M
Fonager RF
Albertsen S
Fledelius J
Ejlersen JA
Christensen MH
Aleksyniene R
Zacho HD
Source :
Hellenic journal of nuclear medicine [Hell J Nucl Med] 2021 Jan-Apr; Vol. 24 (1), pp. 2-9. Date of Electronic Publication: 2021 Apr 20.
Publication Year :
2021

Abstract

Objective: The correlation between the computer-assisted bone scan index (BSI) responses versus clinical response classification if bone metastases in prostate cancer patients are not clear. We compared changes in BSI with Prostate Cancer Working Group-3 (PCWG3) and MD Anderson (MDA) criteria.<br />Materials and Methods: Fifty-six consecutive patients with at least two bone scans (BS) within 12 months were included, who had BS before and after treatment with the same anticancer agent.<br />Results: Progressive disease (PD) by PCWG3 criteria was seen in 28% of the cases (median BSI increased by 1.69 units) versus non-PD in 72% (BSI change -0.13). MDAnderson showed PD in 34% (BSI increase 0.49), 45% stable disease (BSI change 0.00), and 20% partial responses (BSI decrease 1.44). Absolute BSI changes differed significantly among response categories by PCWG3 and MDA criteria (both P<0.0001). Response classification using dichotomized BSI data (>0/≤0 and >0.3/≤0.3 BSI units) showed a significant correlation with PCWG3 and MDA criteria (all P<0.001). Absolute BSI changes and dichotomized BSI correlated to prostate-specific antigen responses (both P<0.001) but not to clinical responses.<br />Conclusion: Absolute changes in BSI and BSI response classification correlated significantly with standardized clinical response criteria for the assessment of treatment responses of skeletal metastases in prostate cancer.

Details

Language :
English
ISSN :
1790-5427
Volume :
24
Issue :
1
Database :
MEDLINE
Journal :
Hellenic journal of nuclear medicine
Publication Type :
Academic Journal
Accession number :
33866333
Full Text :
https://doi.org/10.1967/s002449912300