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Central nervous system inhibition of pentagastrin-stimulated acid secretion by insulin-like growth factor II.
- Source :
-
Life sciences [Life Sci] 1988; Vol. 42 (21), pp. 2091-6. - Publication Year :
- 1988
-
Abstract
- The ability of intracisternal insulin-like growth factor II (IGF II) to inhibit gastric acid secretion was studied in rats. Centrally-administered IGF II dose-dependently inhibited acid secretion stimulated by pentagastrin. The effect was abolished by vagotomy. IGF II did not inhibit acid secretion stimulated by histamine or PCP-GABA.
- Subjects :
- Animals
Baclofen pharmacology
Cisterna Magna
Dose-Response Relationship, Drug
Histamine pharmacology
Injections
Insulin-Like Growth Factor II administration & dosage
Male
Rats
Rats, Inbred Strains
Silanes administration & dosage
Vagotomy
Gastric Acid metabolism
Insulin-Like Growth Factor II pharmacology
Pentagastrin antagonists & inhibitors
Silanes therapeutic use
Silicon therapeutic use
Somatomedins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 42
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 3386394
- Full Text :
- https://doi.org/10.1016/0024-3205(88)90122-1