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Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes.
- Source :
-
Hepatology communications [Hepatol Commun] 2020 Nov 16; Vol. 5 (4), pp. 559-572. Date of Electronic Publication: 2020 Nov 16 (Print Publication: 2021). - Publication Year :
- 2020
-
Abstract
- This study aimed to examine whether the diagnostic accuracy of four noninvasive tests (NITs) for detecting advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is maintained or is inferior to with or without the presence of type 2 diabetes. Overall, 874 patients with biopsy-proven NAFLD were enrolled. After propensity-score matching by age, sex, and the prevalence of dyslipidemia, 311 patients were enrolled in each group of with or without diabetes. To evaluate the effect of diabetes, we compared the diagnostic accuracy of the fibrosis-4 (FIB-4) index, the NAFLD fibrosis score (NFS), the aspartate aminotransferase to platelet ratio index (APRI), and type IV collagen 7S (COL4-7S) in patients with NAFLD with and without diabetes. The areas under the receiver operating characteristic curve (AUROC) for identifying advanced fibrosis in patients without diabetes were 0.879 for the FIB-4 index, 0.851 for the NFS, 0.862 for the APRI, and 0.883 for COL4-7S. The AUROCs in patients with diabetes were 0.790 for the FIB-4 index, 0.784 for the NFS, 0.771 for the APRI, and 0.872 for COL4-7S. The AUROC of COL4-7S was significantly larger than that of the other NITs in patients with NAFLD with diabetes than in those without diabetes. The optimal high and low cutoff points of COL4-7S were 5.9 ng/mL and 4.8 ng/mL, respectively. At the low cutoff point, the accuracy of COL4-7S was better than that of the other NITs, especially in patients with diabetes. Conclusion: COL4-7S measurement might be the best NIT for identifying advanced fibrosis in NAFLD, especially in NAFLD with diabetes.<br /> (© 2020 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.)
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Cross-Sectional Studies
Diabetes Mellitus, Type 2 blood
Dyslipidemias complications
Female
Humans
Male
Middle Aged
Non-alcoholic Fatty Liver Disease blood
Platelet Count
ROC Curve
Young Adult
Collagen Type IV analysis
Diabetes Mellitus, Type 2 complications
Liver Cirrhosis diagnosis
Non-alcoholic Fatty Liver Disease complications
Non-alcoholic Fatty Liver Disease pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2471-254X
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Hepatology communications
- Publication Type :
- Academic Journal
- Accession number :
- 33860115
- Full Text :
- https://doi.org/10.1002/hep4.1637