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D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction.
- Source :
-
PloS one [PLoS One] 2021 Apr 15; Vol. 16 (4), pp. e0249487. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Erectile dysfunction (ED) is defined as the inability to achieve and/or maintain penile erection sufficient for satisfactory sexual relations, and aging is one of the main risk factors involved. The D-(+)-Galactose aging model is a consolidated methodology for studies of cardiovascular aging; however, its potential for use with ED remain unexplored. The present study proposed to characterize a new experimental model for ED, using the D-(+)-Galactose aging model. For the experiments, the animals were randomly divided into three groups receiving: vehicle (CTL), D-galactose 150 mg/kg (DGAL), and D-(+)-galactose 150 mg/Kg + sildenafil 1.5 mg/Kg (DGAL+SD1.5) being administered daily for a period of eight weeks. All of the experimental protocols were previously approved by the Ethics Committee on the Use of Animals at the Federal University of Paraíba n° 9706070319. During the treatment, we analyzed physical, molecular, and physiological aspects related to the aging process and implicated in the development of ED. Our findings demonstrate for the first time that D-(+)-Galactose-induced aging represents a suitable experimental model for ED assessment. This was evidenced by an observed hyper-contractility in corpora cavernosa, significant endothelial dysfunction, increased ROS levels, an increase in cavernous tissue senescence, and the loss of essential penile erectile components.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
Disease Models, Animal
Electric Stimulation
Erectile Dysfunction metabolism
Galactose pharmacology
Male
Penile Erection
Penis pathology
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Sildenafil Citrate adverse effects
Sildenafil Citrate pharmacology
Aging drug effects
Erectile Dysfunction etiology
Galactose adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 33857158
- Full Text :
- https://doi.org/10.1371/journal.pone.0249487