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The rapid effects of sleeve gastrectomy on glucose homeostasis and resolution of diabetes mellitus.
- Source :
-
Endocrinology, diabetes & metabolism [Endocrinol Diabetes Metab] 2020 Aug 30; Vol. 4 (2), pp. e00182. Date of Electronic Publication: 2020 Aug 30 (Print Publication: 2021). - Publication Year :
- 2020
-
Abstract
- Aims: Type 2 diabetes caused by obesity is increasing globally. Bariatric surgical procedures are known to have positive effects on glucose homeostasis through neurohormonal action mechanisms. In the present study, we aimed to investigate the factors influencing glucose homeostasis independent of weight loss after the laparoscopic sleeve gastrectomy (LSG).<br />Methods: Patients who underwent LSG for morbid obesity in a 3-year period were evaluated. Data on demographics, clinical characteristics (duration of diabetes, resected gastric volume, antral resection margin) and laboratory parameters (preoperative and postoperative blood glucose on fasting, preoperative HbA1c levels and first-year HbA1c levels) were retrospectively reviewed. Effect of patients' body mass index (<50 kg/m <superscript>2</superscript> , ≥50 kg/m <superscript>2</superscript> ), first-year excess weight loss (EWL%) rates, age (≥50 years, <50 years), duration of diabetes (≥5 years, <5 years) and antral resection margin (≥3 cm, <3 cm) on postoperative blood glucose profile and diabetic resolution status were investigated.<br />Results: Total of 61 patients constituted the study group. There were 40 female and 21 male patients with an average age of 43.8 ± 10.5 years (19-67 years). Preoperatively, mean BMI, blood glucose levels and HbA1c were 48.8 ± 8.5 kg/m <superscript>2</superscript> , 133.6 ± 47.4 mg/dL and 7.4 ± 1.1, respectively. The mean blood glucose level at the postoperatively 5th day was 88.0 ± 16.3 mg/dL (median: 84 mg/dL) ( P  < .001). Fifty-nine out of 61 patients improved their glycaemic control.<br />Conclusions: It is noteworthy that LSG can control blood glucose levels in short term after surgery regardless of weight loss. Therefore, LSG should be preferred at earlier stages in the treatment of obesity-related T2DM in order to prevent T2DM-related complications.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Biomarkers blood
Diabetes Complications etiology
Diabetes Complications prevention & control
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 etiology
Female
Glycated Hemoglobin
Humans
Male
Middle Aged
Obesity, Morbid complications
Obesity, Morbid surgery
Retrospective Studies
Treatment Outcome
Young Adult
Blood Glucose metabolism
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 surgery
Gastrectomy methods
Homeostasis
Laparoscopy methods
Subjects
Details
- Language :
- English
- ISSN :
- 2398-9238
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Endocrinology, diabetes & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 33855197
- Full Text :
- https://doi.org/10.1002/edm2.182