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Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure.
- Source :
-
Scientific reports [Sci Rep] 2021 Apr 14; Vol. 11 (1), pp. 8164. Date of Electronic Publication: 2021 Apr 14. - Publication Year :
- 2021
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Abstract
- The cardiac lipid panel (CLP) is a novel panel of metabolomic biomarkers that has previously shown to improve the diagnostic and prognostic value for CHF patients. Several prognostic scores have been developed for cardiovascular disease risk, but their use is limited to specific populations and precision is still inadequate. We compared a risk score using the CLP plus NT-proBNP to four commonly used risk scores: The Seattle Heart Failure Model (SHFM), Framingham risk score (FRS), Barcelona bio-HF (BCN Bio-HF) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score. We included 280 elderly CHF patients from the Cardiac Insufficiency Bisoprolol Study in Elderly trial. Cox Regression and hierarchical cluster analysis was performed. Integrated area under the curves (IAUC) was used as criterium for comparison. The mean (SD) follow-up period was 81 (33) months, and 95 (34%) subjects met the primary endpoint. The IAUC for FRS was 0.53, SHFM 0.61, BCN Bio-HF 0.72, MAGGIC 0.68, and CLP 0.78. Subjects were partitioned into three risk clusters: low, moderate, high with the CLP score showing the best ability to group patients into their respective risk cluster. A risk score composed of a novel panel of metabolite biomarkers plus NT-proBNP outperformed other common prognostic scores in predicting 10-year cardiovascular death in elderly ambulatory CHF patients. This approach could improve the clinical risk assessment of CHF patients.
- Subjects :
- Aged
Bisoprolol therapeutic use
Carvedilol therapeutic use
Cluster Analysis
Female
Heart Disease Risk Factors
Heart Failure metabolism
Humans
Male
Multicenter Studies as Topic
Prognosis
Proof of Concept Study
Randomized Controlled Trials as Topic
Regression Analysis
Survival Analysis
Treatment Outcome
Adrenergic beta-1 Receptor Antagonists therapeutic use
Biomarkers metabolism
Heart Failure drug therapy
Lipidomics methods
Natriuretic Peptide, Brain metabolism
Peptide Fragments metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33854188
- Full Text :
- https://doi.org/10.1038/s41598-021-87776-w