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Effect of Laser-assisted Subepithelial Keratectomy with Mitomycin C on Corneal Optical Density Measured with Confocal Microscopy.
- Source :
-
Optometry and vision science : official publication of the American Academy of Optometry [Optom Vis Sci] 2021 Apr 01; Vol. 98 (4), pp. 350-354. - Publication Year :
- 2021
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Abstract
- Significance: The development of confocal microscopy allows one to obtain high-resolution corneal images like its optical density. Some studies have evaluated the optical density with Scheimpflug cameras in the early post-operative period after photorefractive keratectomy, but no studies have evaluated the long-term evolution of optical density after surface ablation when mitomycin C is used.<br />Purpose: This work aimed to study the changes in corneal optical density measured with confocal microscopy in eyes treated with laser-assisted subepithelial keratectomy (LASEK) and intraoperative mitomycin C (MMC) to correct myopia.<br />Methods: A study of 24 consecutive myopic eyes that underwent LASEK with 0.02% MMC and a control group of 24 healthy nontreated eyes was performed. Optical density was measured using the images by the confocal microscopy of the Heidelberg Retina Tomograph II with the Rostock Cornea Module. An analysis of confocal microscopy images was performed using the ImageJ software to obtain the optical density, in gray-scale units (GSU). The optical density of the stromal bed was evaluated 3 months, 15 months, and 3 years after surgery and was compared with the optical density at the equivalent depth of the stroma in controls.<br />Results: The mean values of optical density for the LASEK group were 81.7 ± 9.7, 78.6 ± 11.7, and 73.6 ± 18.7 GSU at 3 months, 15 months, and 3 years, respectively, and it was 61.8 ± 8.2 GSU for the control group. A statistically higher optical density 3 and 15 months after LASEK with MMC was found compared with controls (P < .001). No significant difference was found in optical density at 3 years post-operatively.<br />Conclusions: Our study suggests that, after LASEK with MMC, the anterior corneal stroma has a higher optical density at 3 and 15 months post-operatively, which gradually returns to normal values 3 years after surgery.<br />Competing Interests: Conflict of Interest Disclosure: None of the authors have reported a financial conflict of interest.<br /> (Copyright © 2021 American Academy of Optometry.)
- Subjects :
- Adult
Biometry
Combined Modality Therapy
Cornea diagnostic imaging
Cornea drug effects
Corneal Stroma diagnostic imaging
Corneal Stroma drug effects
Corneal Stroma physiopathology
Female
Humans
Male
Microscopy, Confocal
Middle Aged
Myopia diagnostic imaging
Myopia physiopathology
Prospective Studies
Young Adult
Alkylating Agents administration & dosage
Cornea physiopathology
Keratectomy, Subepithelial, Laser-Assisted methods
Lasers, Excimer therapeutic use
Mitomycin administration & dosage
Myopia surgery
Refraction, Ocular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1538-9235
- Volume :
- 98
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Optometry and vision science : official publication of the American Academy of Optometry
- Publication Type :
- Academic Journal
- Accession number :
- 33852551
- Full Text :
- https://doi.org/10.1097/OPX.0000000000001678