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Dual Functional Pd-Catalyzed Multicomponent Reaction by Umpolung Chemistry of the Oxygen Atom in Electrophiles.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2021 May 07; Vol. 86 (9), pp. 6847-6854. Date of Electronic Publication: 2021 Apr 12. - Publication Year :
- 2021
-
Abstract
- A Pd-catalyzed multicomponent reaction was developed by trapping oxomium ylide with nitrosobenzene via Pd-promoted umpolung chemistry. The Pd catalyst plays two important roles: diazo compound decomposed catalyst and Lewis acid for the activation of nitrosobenzene. This strategy provides some insight into a new way for discovery of multicomponent methodology to construct complex molecules. The developed method also provides rapid access to a series of O -(2-oxy) hydroxylamine derivatives, which exhibit good anticancer activity in osteosarcoma cells.
- Subjects :
- Catalysis
Lewis Acids
Oxygen
Palladium
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 86
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33844915
- Full Text :
- https://doi.org/10.1021/acs.joc.0c02413